iron profile and inflammatory status of overweight and obese women in sari, north of iran

background: several studies have suggested that obesity-related inflammation can lead to altered iron metabolism as well as higher rates of iron deficiency in obese than in normal-weight subjects. given that at a population level, premenopausal women are at higher risk of iron deficiency, the purpose of this study was to investigate iron and inflammatory status in young overweight and obese women. methods: in this study, 120 young and healthy women with a bmi ≥ 25 kg/m2 were attended. biochemical data including iron profile and inflammatory markers were analyzed using mean ± standard deviation or median (interquartile range) and multivariate multiple regression model via manova. results: iron deficiency anemia (hemoglobin < 120 g/l) and iron deficiency without anemia (serum ferritin<30.0 mg/l) were detected in 21.67% and 33.33% of participants respectively. multivariate modeling showed that bmi was a significant predictor of transferrin saturation (p = 0.037), crp (p = 0.013), soluble transferrin receptor (p=0.045), soluble transferrin receptor/ferritin ratio (0.015). conclusion: the results of this study supported the positive association between obesity and inflammation and mild changes in iron markers.